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Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy
Ahmad Golaraei1, Richard Cisek1, Serguei Krouglov1
1Department of Physics and Institute for Optical Sciences, University of Toronto, 60 Saint George Street, Toronto, ON M5S1A7, Canada ; Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L1C6, Canada.
Biomedical Optics Express
|November 1, 2014
Abstract:
Polarization second harmonic microscopy was used for collagen imaging in human non-small cell lung carcinoma and normal lung tissues ex vivo and revealed significant differences in the nonlinear susceptibility component ratio, demonstrating potential use in cancer diagnosis.
