Related Experiment Video
Updated: Apr 21, 2026
06:24
Author Spotlight: Liujunzi Decoction as a Traditional Chinese Treatment for Coloproctitis Cancer
Published on: October 13, 2023
1.8K
LIN28B promotes colon cancer migration and recurrence
Minghui Pang1, Gang Wu1, Xiaolin Hou1
1Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
Plos One
|November 1, 2014
Summary
LIN28B (a protein involved in stemness) promotes colon cancer migration and recurrence. Suppressing LIN28B inhibits cancer cell movement and enhances chemotherapy effectiveness, suggesting LIN28B as a potential therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- LIN28B regulates microRNA maturation, impacting cellular processes like stemness and tumor development.
- LIN28B's role in colon cancer progression, particularly its influence on cell migration and treatment response, requires further elucidation.
Purpose of the Study:
- To investigate the expression and function of LIN28B in colon cancer.
- To determine the correlation between LIN28B overexpression and patient survival and tumor recurrence.
- To assess the impact of LIN28B suppression on colon cancer cell migration and chemosensitivity.
Main Methods:
- Immunohistochemistry and RT-PCR were used to quantify LIN28B expression in colon cancer tissues and cells.
- In vitro assays, including loss-of-function, migration, and proliferation analyses, were conducted.
- Chemosensitivity assays were performed using oxaliplatin.
Main Results:
- LIN28B was significantly upregulated in colon cancer tissues compared to normal mucosa.
- LIN28B overexpression correlated with poorer patient survival and increased tumor recurrence rates.
- LIN28B suppression inhibited colon cancer cell migration and enhanced sensitivity to oxaliplatin.
Conclusions:
- LIN28B overexpression is a driver of colon tumorigenesis and progression.
- LIN28B may serve as a valuable diagnostic biomarker for colon cancer.
- Targeting LIN28B presents a potential therapeutic strategy for colon cancer treatment.
Related Concept Videos
01:35Cancer Cell Migration through Invadopodia
2.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.4K
02:07Tumor Progression
6.1K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.1K