[Establishment and evaluation on the animal models with coronary microcirculation dysfunction]

Area of Science:

• Cardiovascular Research
• Animal Models
• Physiology

Context:

• Coronary microcirculation dysfunction is a key area in cardiovascular research.
• Understanding its pathology and intervention mechanisms requires reliable animal models.
• Current models often involve coronary microembolization or microthrombosis.

Purpose:

• To summarize existing preparation techniques for animal models of coronary microcirculation dysfunction.
• To compare the advantages and disadvantages of different modeling methods.
• To provide a resource for researchers selecting appropriate animal models.

Summary:

• This paper reviews methods for creating animal models of coronary microcirculation dysfunction.
• Techniques discussed include mechanical obstruction and chemical damage leading to microembolization or microthrombosis.
• A comparative analysis of these preparation methods is presented.

Impact:

• Facilitates the selection of optimal animal models for studying coronary microcirculation dysfunction.
• Aids in advancing research on the pathology and treatment of related cardiovascular diseases.
• Supports the development of more effective intervention strategies through improved preclinical research.