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Mouse natural autoantibodies can interfere with murine alpha and beta interferons
P Matsiota1, M F Saron, J C Guillon
1Unite d'Immunocytochimie, Institut Pasteur, Paris, France.
Journal of Virology
|February 1, 1989
Abstract:
Natural polyspecific autoantibodies could impede the establishment of an antiviral state by mouse alpha and beta interferons (IFN) as determined by an IFN assay with L929 cells and with vesicular stomatitis virus as the challenge virus. This anti-IFN effect was due to interactions with cell surface constituents rather than to antibody activity against IFN. This observation supports the hypothesis that natural autoantibodies participate in specific immune regulation as well as in the regulation of nonspecific host defense.