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Published on: January 11, 2013
Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain
Nathalie Van Den Berge1, Vincent Keereman, Christian Vanhove
1Medical Image and Signal Processing Group, Medical IT Department, Ghent University-iMinds, Ghent, Belgium, Nathalie.VanDenBerge@ugent.be.
Purpose:
The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography ([(18)F]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats.
Procedures:
Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [(18)F]FDG to measure the glucose metabolism during DBS.
Results:
Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures.
Conclusions:
This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [(18)F]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.
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