Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain
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Updated: Apr 21, 2026
Hippocampal Insulin Microinjection and In vivo Microdialysis During Spatial Memory Testing
Published on: January 11, 2013
Nathalie Van Den Berge1, Vincent Keereman, Christian Vanhove
1Medical Image and Signal Processing Group, Medical IT Department, Ghent University-iMinds, Ghent, Belgium, Nathalie.VanDenBerge@ugent.be.
Purpose:
The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography ([(18)F]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats.
Procedures:
Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [(18)F]FDG to measure the glucose metabolism during DBS.
Results:
Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures.
Conclusions:
This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [(18)F]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.
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