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Published on: March 11, 2021
Motoric cognitive risk syndrome: Multicenter incidence study
Joe Verghese1, Emmeline Ayers2, Nir Barzilai2
1From the Departments of Neurology (J.V., E.A., R.H., M.J.K., R.B.L.), Medicine (J.V., N.B.), and Epidemiology and Population Health (R.B.L., C.W.), Albert Einstein College of Medicine, Bronx, NY; Rush Alzheimer's Disease Center (D.A.B., A.S.B.), Rush University Medical Center, Chicago, IL; and Ferkauf School of Psychology (R.H.), Yeshiva University, Bronx, NY. joe.verghese@einstein.yu.edu.
Motoric cognitive risk syndrome (MCR) affects older adults at a high incidence rate. Modifiable factors like stroke, Parkinson disease, depression, inactivity, and obesity increase MCR risk, aiding early identification and prevention strategies.
Area of Science:
- Gerontology
- Neurology
- Epidemiology
Background:
- Motoric cognitive risk syndrome (MCR) is a newly identified predementia syndrome.
- It is characterized by the co-occurrence of slow gait and cognitive complaints.
Purpose of the Study:
- To determine the incidence rates of MCR in older adults.
- To identify modifiable risk factors associated with the development of MCR.
Main Methods:
- Analysis of data from 3,128 adults aged 60+ from four US-based cohort studies.
- Cox models were used to calculate hazard ratios for modifiable risk factors predicting MCR incidence.
Main Results:
- The overall incidence of MCR was 65.2 per 1,000 person-years.
- Risk factors for MCR included older age, stroke, Parkinson disease, depressive symptoms, sedentariness, and obesity.
- Incidence was higher in older age groups, with no significant sex differences.
Conclusions:
- MCR has a high incidence in the elderly population.
- Identifying modifiable risk factors is crucial for early detection and intervention.
- These findings can guide strategies to prevent cognitive decline in aging individuals.
