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Updated: Apr 21, 2026

Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation
Published on: December 29, 2014
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia
Carl M Gay1, William N William1, Sa A Wang1
1From the Department of Medicine, University of Texas Health Science Center; and the Department of Thoracic/Head and Neck Medical Oncology, Department of Hematopathology, and Section of Thrombosis & Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abstract:
Although the association of pure red cell aplasia (PRCA) and aplastic anemia with thymoma is well-known, acquired amegakaryocytic thrombocytopenia (AAMT) is not a recognized paraneoplastic manifestation of thymoma. This report discusses a patient with recurrent thymoma complicated by myasthenia gravis, PRCA, and AAMT. Both PRCA and AAMT are diagnosed after a thymoma recurrence, 11 years after complete resection of the initial tumor and 9 months after chemotherapy for the relapsed disease. Both PRCA and AAMT responded to immunosuppression with cyclosporine, corticosteroid, and an abbreviated course of antithymocyte globulin, achieving a very good erythroid response and a complete remission for AAMT, suggesting that AAMT, although extremely rare, can be an immune-mediated paraneoplastic manifestation of thymoma.
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