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Development and pilot testing of a vitiligo screening tool.

Vaneeta M Sheth¹, Nicole S Gunasekera, Sujeeta Silwal

¹Brigham and Women's Hospital (BWH), Boston, MA, USA, vsheth@partners.org.

Archives of Dermatological Research

|November 2, 2014

Summary

This summary is machine-generated.

The Vitiligo Screening Tool (VISTO) accurately identifies vitiligo in adults. This self-administered questionnaire demonstrates high sensitivity and specificity, improving research subject identification for vitiligo studies.

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Area of Science:

Dermatology
Epidemiology
Clinical Research

Background:

Current vitiligo research relies on self-reported physician diagnoses, which are insufficient for accurate subject identification.
A validated screening tool is needed to improve the precision of vitiligo patient recruitment for studies.

Purpose of the Study:

To evaluate the sensitivity and specificity of the patient-administered Vitiligo Screening Tool (VISTO) for detecting vitiligo in adults.
To assess VISTO's utility as a tool for identifying vitiligo patients for clinical trials and epidemiological data collection.

Main Methods:

159 adult patients from a dermatology clinic were recruited, with or without a vitiligo diagnosis.
Participants completed the VISTO, an eight-question tool including characteristic images and descriptions of vitiligo lesions.
A board-certified dermatologist confirmed or excluded vitiligo diagnoses in all subjects; 147 questionnaires were analyzed.

Main Results:

The VISTO's pictorial question demonstrated 97.9% sensitivity and 98% specificity for vitiligo diagnosis.
Combining a 'yes' response to prior dermatologist diagnosis with selecting a photographic representation yielded 95.2% sensitivity and 100% specificity.
The tool is a low-burden, self-administered method for identifying vitiligo in adult English speakers.

Conclusions:

The Vitiligo Screening Tool (VISTO) is a highly sensitive and specific instrument for adult vitiligo detection.
VISTO offers a simple, cost-effective method for confirming vitiligo before clinical trial enrollment and for large-scale data gathering.
Further refinement of VISTO is recommended for future genotype-phenotype correlation studies.