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Plasma exchanges and immunosuppression for anti-complement factor H associated hemolytic uremic syndrome
Priyanka Khandelwal1, Aditi Sinha, Pankaj Hari
1Division of Pediatric Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Correspondence to: Dr Arvind Bagga, Division of Pediatric Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India. arvindbagga@hotmail.com.
Background:
Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure.
Case Characteristics:
7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies.
Intervention:
Prompt initiation of plasma exchanges and immunosuppression.
Outcome:
Remission of hematological and kidney functions.
Message:
Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.
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