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Osseous sarcoidosis: a case series.

Halyna Kuzyshyn1, David Feinstein, Sharon L Kolasinski

  • 1Division of Rheumatology, Cooper University Hospital, Camden, NJ, 08103, USA, khalyna@gmail.com.

Rheumatology International
|November 3, 2014
PubMed
Summary

Sarcoidosis can affect bones, including long bones and vertebrae, presenting diagnostic challenges. This study reviews imaging techniques and immunosuppressive therapies for skeletal sarcoidosis.

Area of Science:

  • Rheumatology
  • Radiology
  • Immunology

Background:

  • Sarcoidosis is a multisystem inflammatory disease often affecting the lungs.
  • Skeletal involvement, or osseous sarcoidosis, occurs in a significant minority of patients.
  • Diagnosis and assessment of skeletal sarcoidosis can be challenging due to varied presentation.

Observation:

  • Plain radiography is effective for detecting lesions in small bones of hands and feet.
  • Bone scans help delineate the extent of skeletal disease and bone marrow involvement.
  • MRI reveals characteristic multifocal vertebral lesions, hypointense on T1 and hyperintense on T2 weighted images.

Findings:

  • The study presents five cases of multisystem sarcoidosis with diverse skeletal involvement, including long bones and vertebrae.

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  • It highlights the utility of various imaging modalities in diagnosing bone sarcoidosis.
  • Immunosuppressive therapies were employed in the presented cases, with treatment strategies discussed.

    • Implications:

    • Early and accurate diagnosis of osseous sarcoidosis is crucial for appropriate management.
    • Further research is needed to establish optimal treatment protocols for skeletal sarcoidosis.
    • This work contributes to understanding the diagnostic imaging and therapeutic approaches for bone involvement in sarcoidosis.