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Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Exercise, neurotrophins, and axon regeneration in the PNS
Arthur W English1, Jennifer C Wilhelm2, Patricia J Ward3
1Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and medae@emory.edu.
Abstract:
Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.

