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Updated: Apr 21, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 23, 2014
Making microvascular networks work: angiogenesis, remodeling, and pruning
Axel R Pries1, Timothy W Secomb2
1Department of Physiology and CCR, Charité, Berlin, Germany; Deutsches Herzzentrum Berlin, Berlin, Germany; axel.pries@charite.de.
Abstract:
The adequate and efficient functioning of the microcirculation requires not only numerous vessels providing a large surface area for transport but also a structure that provides short diffusion distances from capillaries to tissue and efficient distribution of convective blood flow. Theoretical models show how a combination of angiogenesis, remodeling, and pruning in response to hemodynamic and metabolic stimuli, termed "angioadaptation," generates well organized, functional networks.
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