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Serum prohepcidin levels in premature newborns with oxygen radical diseases

H Tolga Çelik1, Murat Yurdakök2, Ayşe Korkmaz2

  • 1a Division of Neonatology, Department of Pediatrics , Dr, Hacettepe University Faculty of Medicine , Ankara , Turkey and.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|November 4, 2014
PubMed

Insights

Premature newborns with oxygen radical diseases had higher prohepcidin and ferritin levels than healthy infants. This study explores the link between inflammation and hepcidin in these conditions.

Area of Science:

  • Neonatology
  • Pediatric Medicine
  • Biochemistry

Background:

  • Oxygen radical diseases are a significant concern in premature infants.
  • Conditions like bronchopulmonary dysplasia, retinopathy of prematurity, and necrotizing enterocolitis are linked to oxidative stress.
  • Understanding the biomarkers associated with these diseases is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate prohepcidin levels in premature newborns diagnosed with oxygen radical diseases.
  • To compare prohepcidin concentrations between premature infants with and without these oxidative stress-related conditions.
  • To explore potential correlations between prohepcidin, iron parameters, and oxygen radical diseases in neonates.

Main Methods:

  • Study included 80 premature infants (25-34 weeks gestational age).
  • Participants were divided into a patient group (38 infants with oxygen radical diseases) and a control group (42 healthy premature infants).
  • Measurements included complete blood count, serum iron, ferritin, iron-binding capacity (IBC), transferrin, and prohepcidin levels.

Main Results:

  • Mean serum ferritin levels were significantly higher in the patient group compared to the control group (p=0.038).
  • Mean serum prohepcidin levels were also significantly elevated in the patient group versus the control group (p=0.022).
  • No significant correlations were identified between serum prohepcidin levels and measured iron parameters.

Conclusions:

  • Elevated prohepcidin levels in premature infants with oxygen radical diseases suggest a potential role in their pathogenesis.
  • The findings contribute to understanding the etiopathogenesis of these neonatal oxidative stress-related conditions.
  • Further research is warranted to elucidate the relationship between inflammatory mechanisms, hepcidin, and oxygen radical diseases in neonates.

Keywords:
Hepcidinnewbornsoxygen radical diseasespremature

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