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Cognition, structural brain changes and complicated grief. A population-based study.

H C Saavedra Pérez1, M A Ikram1, N Direk1

  • 1Department of Epidemiology,Erasmus Medical Center,Rotterdam,The Netherlands.

Psychological Medicine
|November 4, 2014
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Summary
This summary is machine-generated.

Complicated grief is linked to poorer cognitive function and smaller brain volumes. These findings suggest a potential neurological basis for complicated grief in the general population.

Keywords:
structural brain volumes

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Psychosocial factors are known risks for complicated grief.
  • The link between complicated grief and cognitive/biological factors remains unclear.

Purpose of the Study:

  • To investigate the association between complicated grief and cognitive performance.
  • To examine the relationship between complicated grief and structural brain volumes.

Main Methods:

  • Cross-sectional analysis of 5501 non-demented individuals from the Rotterdam Study.
  • Assessment of grief severity using the Inventory of Complicated Grief.
  • Cognitive testing and magnetic resonance imaging (MRI) for brain volume and white matter lesions.

Main Results:

  • Complicated grief was associated with lower scores on the Letter-Digit Substitution Test and Word Fluency Task.
  • Individuals with complicated grief exhibited smaller total brain volumes compared to those without grief.
  • No significant associations were found for normal grief.

Conclusions:

  • Complicated grief is associated with impaired cognitive performance and reduced total brain volume.
  • These findings suggest a potential neurological correlate for complicated grief.
  • Normal grief did not show similar cognitive or structural brain associations.