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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

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Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Oral Crohn's disease.

Bn Padmavathi1, Smriti Sharma1, Madhusudan Astekar2

  • 1Department of Oral Medicine, Radiology and Diagnosis, Darshan Dental College and Hospital, Loyara, Udaipur, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|November 4, 2014
PubMed
Summary

Early diagnosis of Crohn's disease is possible through oral examinations. Orofacial symptoms can appear years before intestinal issues, aiding in early histological diagnosis.

Keywords:
Crohn's diseasechroniccobblestonecolitisgranulomagranulomatous diseasegranulomatous enteritisoralpediatric crohn

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Area of Science:

  • Gastroenterology
  • Oral Medicine
  • Inflammatory Diseases

Background:

  • Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract.
  • It can manifest with extra-intestinal symptoms, including oral lesions.
  • Early diagnosis is crucial for effective management and improved patient outcomes.

Observation:

  • A case study highlights orofacial Crohn's disease with a 13-year history of oral symptoms.
  • The patient also experienced intermittent constipation for six months.
  • Oral examination revealed significant findings related to the condition.

Findings:

  • Oral lesions can precede the onset of intestinal Crohn's disease.
  • Histological examination of oral lesions can provide a diagnosis.
  • This case underscores the diagnostic value of oral manifestations.

Implications:

  • Oral examinations are vital for the early detection of Crohn's disease.
  • Recognizing orofacial symptoms can lead to timely intervention.
  • This approach may improve the diagnostic timeline for Crohn's disease.