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Updated: Apr 21, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
Role of DNA methylation and the DNA methyltransferases in learning and memory
Michael J Morris1, Lisa M Monteggia2
1Department of Biological Sciences, University of Michigan-Dearborn, Dearborn, Michigan, USA.
Abstract:
Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in learning and memory. Methylation of cytosine nucleotides has historically been considered the strongest and least modifiable of epigenetic marks. Accumulating recent data suggest that rapid and dynamic methylation and demethylation of specific genes in the brain may play a fundamental role in learning, memory formation, and behavioral plasticity. The current review focuses on the emergence of data that support the role of DNA methylation and demethylation, and its molecular mediators in memory formation.
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