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Primary intravascular large B-cell lymphoma of the lung: a review and case report
Yanfan Chen1, Cheng Ding1, Quan Lin1
11 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Objective:
To investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung.
Methods:
Histopathological and clinical data based on lung biopsy were analyzed and used to diagnose a patient with IVLBCL of the lung.
Results:
Fever and respiratory symptoms were the main presentations, lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed Bcl-2, the Bcl-6, CD20, Ki67, MUM-1, Pax5, CD, CD30, and vascular endothelial CD34.
Conclusions:
Primary pulmonary IVLBCL of the lung is extremely rare, on chest CT it manifests as diffuse ground glass shadow, or nodular consolidations in the lung, lactate dehydrogenase and C-reactive protein was found to increase, fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is an important and significant diagnostic modality in its early diagnosis. Also, bronchial lung biopsy has the advantage of less trauma and high sensitive rate. R-CHOP is the main treatment for lung primary pulmonary IVLBCL of the lung; however, its prognosis is relatively poor.
