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Related Experiment Video

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Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
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Mouse Models of Bariatric Surgery.

Deng Ping Yin1, Kelli L Boyd2, Phillip E Williams3

  • 1Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA ; Department of Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Current Protocols in Mouse Biology
|November 4, 2014
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Summary

Bariatric surgery is the most effective obesity treatment. This study details surgical procedures in genetic mouse models to advance understanding of the gut

Keywords:
Bariatric surgeryRoux-en-Y gastric bypassbiliopancreatic diversionduodenal-jejunal bypassgastric bandingmicesleeve gastrectomy

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Area of Science:

  • Metabolic disease research
  • Surgical innovation
  • Obesity treatment

Background:

  • Morbid obesity is associated with numerous health issues like diabetes and cardiovascular disease.
  • Lifestyle changes and drug therapies are often ineffective for obesity management.
  • Bariatric surgery is the most effective treatment for obesity and its related metabolic disorders.

Purpose of the Study:

  • To present detailed methods for bariatric surgical procedures in genetic mouse models.
  • To facilitate a deeper understanding of the gut's role in metabolic diseases through surgical modeling.
  • To provide a foundation for future research into obesity and metabolic disorders.

Main Methods:

  • Development and application of genetic mouse models for bariatric surgery.
  • Detailed surgical techniques including gastric banding, sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), duodenal-jejunal bypass (DJB), and biliopancreatic diversion (BPD).
  • Mimicking human bariatric surgical procedures in a preclinical setting.

Main Results:

  • Established a suite of bariatric surgical models in genetic mice.
  • Provided detailed methodologies for replicating various human bariatric procedures.
  • Created a platform for investigating the gut's contribution to metabolic disease.

Conclusions:

  • Bariatric surgery in genetic mouse models offers a powerful tool for studying metabolic disease.
  • These models will enhance our comprehension of how surgical interventions impact gut function and metabolic health.
  • This research paves the way for improved therapeutic strategies for obesity and related conditions.