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Cognitive function in subclinical hypothyroidism in elderly.

Sarita Bajaj1, Shivam Sachan1, Vatsala Misra2

  • 1Department of Medicine, Swaroop Rani Nehru Hospital, Allahabad, Uttar Pradesh, India.

Indian Journal of Endocrinology and Metabolism
|November 4, 2014
PubMed
Summary
This summary is machine-generated.

Cognitive impairment is more common in elderly individuals with subclinical hypothyroidism. Higher thyroid-stimulating hormone (TSH) levels correlate with declining cognitive function in these patients.

Keywords:
Cognitive impairmentelderlysubclinical hypothyroidism

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Neuroscience

Background:

  • Subclinical hypothyroidism (SCH) is common in the elderly.
  • Cognitive decline is a significant concern in aging populations.
  • The relationship between SCH and cognitive function requires further investigation.

Purpose of the Study:

  • To investigate the association between subclinical hypothyroidism and cognitive function in elderly individuals.
  • To compare cognitive performance in elderly patients with SCH versus healthy controls.

Main Methods:

  • A cross-sectional, case-control study involving 103 elderly patients (≥65 years) with SCH and 103 matched healthy controls.
  • Serum TSH, free T3, and free T4 levels were measured.
  • Cognitive function was assessed using the Folstein Mini-Mental Examination (MMSE) and the Clock Drawing Test (CDT).

Main Results:

  • Cognitive impairment was significantly more prevalent in the SCH group (30.9% by MMSE) compared to controls (14.54%, P=0.003).
  • No significant difference in cognitive impairment was observed between groups using the CDT (P>0.05).
  • Elderly patients with SCH and cognitive impairment had higher mean TSH levels (7.67 ± 1.22 mIU/L) than those without cognitive impairment (6.47 ± 0.98 mIU/L, P=0.0001).

Conclusions:

  • The prevalence of cognitive impairment is significantly higher in elderly individuals with subclinical hypothyroidism.
  • Cognitive function decline in SCH is associated with elevated TSH levels, indicating a dose-dependent relationship.