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CMOS time-resolved, contact, and multispectral fluorescence imaging for DNA molecular diagnostics
Nan Guo1, Kawai Cheung2, Hiu Tong Wong3
1Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. nanguo-c@my.cityu.edu.hk.
Sensors (Basel, Switzerland)
|November 4, 2014
Summary
Complementary metal-oxide-semiconductor (CMOS) technology enables sensitive, low-cost fluorescence analysis for point-of-care deoxyribonucleic acid (DNA) detection. This review surveys CMOS microsystems, overcoming limitations of bulky, expensive traditional fluorescence instruments.
Area of Science:
- Biomedical Engineering
- Molecular Diagnostics
- Optoelectronics
Background:
- Traditional fluorescence techniques for deoxyribonucleic acid (DNA) detection are limited by bulkiness and high cost, hindering widespread point-of-care applications.
- Complementary metal-oxide-semiconductor (CMOS) technology offers advantages like high integration, advanced signal processing, and low power consumption.
Purpose of the Study:
- To review the application of CMOS technology in fluorescence analysis for molecular diagnostics.
- To highlight the state-of-the-art in CMOS-based fluorescence analysis microsystems.
Main Methods:
- Review of CMOS time-resolved, contact, and multispectral imaging techniques.
- Survey of recently reported CMOS fluorescence analysis microsystem prototypes.
Main Results:
- CMOS technology enables the development of sensitive, integrated, and low-cost fluorescence analytical platforms.
- Prototypes demonstrate the feasibility of CMOS-based solutions for in-field molecular diagnostics.
Conclusions:
- CMOS technology is a promising solution to overcome the limitations of conventional fluorescence instruments for point-of-care diagnostics.
- Further development of CMOS microsystems can lead to more accessible and ubiquitous molecular diagnostic tools.
