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Blastocystis is associated with decrease of fecal microbiota protective bacteria: comparative analysis between
Céline Nourrisson1, Julien Scanzi2, Bruno Pereira3
1CHU Clermont-Ferrand, Centre de Biologie, Laboratoire de Parasitologie-Mycologie, Hôpital G. Montpied, Clermont-Ferrand, France; Clermont Université, Université Blaise Pascal, Laboratoire Microorganismes: Génome et Environnement, BP 10448, Clermont-Ferrand, France; CNRS, UMR 6023, LMGE, Aubière, France.
Blastocystis, an intestinal parasite, is more prevalent in Irritable Bowel Syndrome (IBS) patients, especially men. Its carriage may alter gut bacteria, potentially contributing to IBS pathophysiology and constipation.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Blastocystis is a common human intestinal parasite.
- Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder.
- Blastocystis is suspected to be linked to IBS pathophysiology.
Purpose of the Study:
- To compare Blastocystis prevalence in IBS patients and controls.
- To conduct a meta-analysis on Blastocystis and IBS association.
- To investigate the impact of Blastocystis on gut microbiota in IBS.
Main Methods:
- Prevalence study comparing 56 IBS patients and 56 controls.
- Meta-analysis of epidemiological studies on Blastocystis and IBS.
- Quantification of 8 major enteric bacterial groups.
Main Results:
- Higher Blastocystis prevalence in IBS patients, significant in men.
- Meta-analysis showed a 2.34 relative risk of Blastocystis infection in IBS patients.
- Blastocystis carriage linked to decreased Bifidobacterium in men with IBS-C and decreased Faecalibacterium prausnitzii in male controls.
Conclusions:
- Blastocystis may play a role in IBS pathophysiology, particularly IBS-C.
- Blastocystis carriage is associated with gut microbiota imbalance.
- Further research is needed to elucidate the mechanisms linking Blastocystis to IBS.
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