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Invasive pulmonary infection caused by Chrysosporium articulatum: the first case report

Chusana Suankratay1, Onwalee Dhissayakamol, Noppacharn Uaprasert

  • 1Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Mycoses
|November 5, 2014
PubMed

Insights

This study details the first invasive pulmonary infection caused by Chrysosporium articulatum in a young leukemia patient. The successful treatment with voriconazole offers hope for similar rare fungal infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Hematology

Background:

  • Chrysosporium species are saprobic soil fungi with over 60 known species.
  • Taxonomic confusion exists between Chrysosporium and Emmonsia, particularly regarding adiaspiromycosis.
  • Chrysosporium articulatum was not previously known to cause invasive human infections.

Observation:

  • A 16-year-old male with acute T-cell lymphoblastic leukemia presented with an invasive pulmonary infection.
  • The infection was caused by Chrysosporium articulatum, a species previously unreported in human invasive disease.

Findings:

  • This case represents the first documented instance of invasive pulmonary infection by Chrysosporium articulatum.
  • The patient received successful treatment with the antifungal medication voriconazole.

Implications:

  • This finding expands the known spectrum of Chrysosporium articulatum pathogenicity.
  • Highlights the importance of accurate fungal identification in immunocompromised patients.
  • Voriconazole demonstrates efficacy in treating rare invasive fungal infections caused by Chrysosporium species.
Keywords:
ChrysosporiumChrysosporium articulatumfungal infectioninvasive pulmonary infection

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