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Related Concept Videos

Thermosensation01:43

Thermosensation

29.6K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Mechanically-gated Ion Channels01:12

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Voltage-gated Ion Channels01:26

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
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Voltage-gated Ion Channels01:26

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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Related Experiment Video

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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Thermally activated TRPV3 channels.

Jialie Luo1, Hongzhen Hu1

  • 1The Center for the Study of Itch, Washington University Pain Center, The Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.

Current Topics in Membranes
|November 5, 2014
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Vanilloid 3 (TRPV3) is a temperature-sensitive ion channel. Understanding TRPV3

Keywords:
DermatitisHair morphogenesisInflammationPainPruritusSkin disordersTRPV3thermoTRPS

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Area of Science:

  • * Molecular Biology
  • * Physiology
  • * Pharmacology

Background:

  • * Transient Receptor Potential Vanilloid 3 (TRPV3) is a temperature-sensitive ion channel.
  • * TRPV3 functions as a Ca(2+)-permeable nonselective cation channel, activated by warmth, chemicals, and plant compounds.
  • * Its activity is modulated by various physiological factors like pH, ATP, and arachidonic acid.

Purpose of the Study:

  • * To review current knowledge on TRPV3.
  • * To summarize its tissue expression, structure, function, and activation mechanisms.
  • * To highlight its potential roles in disease and therapeutic interventions.

Main Methods:

  • * Comprehensive literature review.
  • * Analysis of existing research on TRPV3.
  • * Synthesis of data on TRPV3 expression, function, and regulation.

Main Results:

  • * TRPV3 is broadly expressed in neuronal and non-neuronal tissues, including skin keratinocytes and neurons.
  • * TRPV3 null mice show skin barrier defects and hair morphogenesis abnormalities.
  • * Emerging evidence links TRPV3 to inflammatory skin disorders, itch, and pain.

Conclusions:

  • * TRPV3 is a key player in skin biology and sensory pathways.
  • * Modulating TRPV3 activity offers potential therapeutic strategies for various diseases.
  • * Further research into TRPV3 activators and inhibitors is warranted.