Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

2.1K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.1K
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)01:16

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

2.3K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
2.3K
Phosphorylation01:02

Phosphorylation

44.6K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
44.6K
Phosphodiester Linkages01:01

Phosphodiester Linkages

98.8K
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
98.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metallo-inhibition of Mnx, a bacterial manganese multicopper oxidase complex.

Journal of inorganic biochemistry·2021
Same author

Davis-Beirut Reaction Inspired Nitroso Diels-Alder Reaction.

Tetrahedron letters·2021
Same author

Investigation of the physical, optical, and chemical properties of phase segregated AlCoOx thin films from a novel hexol-type cluster.

Dalton transactions (Cambridge, England : 2003)·2021
Same author

1-BENZYLSPIRO[PIPERIDINE-4,1'-PYRIDO[3,4-b]indole] 'co-potentiators' for minimal function CFTR mutants.

European journal of medicinal chemistry·2020
Same author

The Surface Chemistry of Metal Oxide Clusters: From Metal-Organic Frameworks to Minerals.

ACS central science·2020
Same author

Dynamics of Cation-Induced Conformational Changes in Nanometer-Sized Uranyl Peroxide Clusters.

Inorganic chemistry·2020

Related Experiment Video

Updated: Apr 21, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

10.9K

Reversible capping/uncapping of phosphorous-centered Keggin-type polyoxoniobate clusters.

Jung-Ho Son1, William H Casey

  • 1Department of Chemistry, University of California, Davis One Shields Ave. Davis, CA 95616, USA. junghoson@gmail.com.

Chemical Communications (Cambridge, England)
|November 5, 2014
PubMed
Summary

The study demonstrates the removal of caps from polyoxometalates in basic conditions, enabling transmetalation reactions to form new capped structures. This research advances polyoxometalate chemistry and materials science.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

4.9K

Related Experiment Videos

Last Updated: Apr 21, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

10.9K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

4.9K

Area of Science:

  • Inorganic Chemistry
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Polyoxometalates (POMs) are versatile inorganic clusters with tunable properties.
  • α-Keggin-type POMs, specifically [PM2Nb12O40](9-), possess cap structures that influence their reactivity.
  • Understanding the manipulation of these cap structures is crucial for designing novel POM-based materials.

Purpose of the Study:

  • To investigate the removal of cap ligands from α-Keggin-type polyoxometalates.
  • To explore the subsequent transmetalation and capping reactions using the uncapped POMs.
  • To synthesize novel polyoxometalate structures with specific metal substitutions.

Main Methods:

  • Treatment of [PM2Nb12O40](9-) with basic conditions to achieve decapping.
  • Reaction of uncapped [PNb12O40](15-) or related species with metal oxides (Sb2O3, V2O5).
  • Characterization of the resulting polyoxometalate products using appropriate analytical techniques.

Main Results:

  • Successful removal of cap ligands from [PM2Nb12O40](9-) under basic conditions, yielding [PNb12O40](15-).
  • Demonstration of transmetalation and capping reactions involving [PNb14O42](9-) or [PNb12O40](15-) with Sb2O3 and V2O5.
  • Formation of novel capped polyoxometalates: [PSb2Nb12O40](9-) and [PV2Nb12O42](9-).

Conclusions:

  • The cap structure of α-Keggin-type polyoxometalates can be selectively removed in basic media.
  • Decapped polyoxometalates serve as effective precursors for transmetalation and capping reactions.
  • This methodology allows for the synthesis of new POMs with tailored compositions and properties.