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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

8
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Related Experiment Video

Updated: Apr 21, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
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Colonoscopy after spinal cord injury: a case-control study.

B P Morris1, T Kucchal1, A N Burgess1

  • 1Department of Colorectal Surgery, Austin Hospital, Melbourne, VIC, Australia.

Spinal Cord
|November 5, 2014
PubMed
Summary

Colonoscopy in spinal cord injury (SCI) patients shows lower polyp detection due to poorer bowel preparation and completion rates. However, malignancy risk remains similar to the general population.

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Epidemiology

Background:

  • Colonoscopy is a crucial diagnostic tool for colorectal diseases.
  • Spinal cord injury (SCI) may impact gastrointestinal function and patient management.
  • Understanding colonoscopy outcomes in SCI patients is essential for optimizing care.

Purpose of the Study:

  • To compare colonoscopy indications, bowel preparation, technical success, and disease detection between SCI patients and the general population.
  • To evaluate the effectiveness and safety of colonoscopy in individuals with spinal cord injury.

Main Methods:

  • An age- and gender-matched case-control study was conducted in Victoria, Australia.
  • Consecutive SCI colonoscopies (1998-2013) were compared to a control group.

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  • Data collected included injury level, indication, demographics, bowel preparation quality, completion rates, and disease detection.

    • Main Results:

    • 148 SCI patients and 292 controls underwent colonoscopy. SCI patients had more investigations for abnormalities (85.1% vs. 58.2%) and less for screening (18.2% vs. 40.8%).
    • Unsatisfactory bowel preparation (36.0% vs. 13.0%) and lower completion rates (75.7% vs. 93.1%) were more frequent in SCI patients.
    • Overall disease detection (45.3% vs. 59.6%) and polyp detection (11.4% vs. 25.3%) were lower in SCI patients, while malignancy rates were similar (2.7% vs. 3.0%).

    Conclusions:

    • Spinal cord injury patients have a similar risk of colorectal malignancy as the general population.
    • Colonoscopy in SCI patients is challenged by poorer bowel preparation and lower completion rates, leading to reduced polyp detection.
    • SCI patients are less likely to undergo colonoscopy for screening purposes.