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Related Experiment Video

Updated: Apr 21, 2026

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Pericellular proteolysis in cancer.

Lisa Sevenich1, Johanna A Joyce2

  • 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA.

Genes & Development
|November 5, 2014
PubMed
Summary

Pericellular proteases play a key role in cancer invasion and metastasis. This review explores how these enzymes, regulated by the tumor microenvironment, drive cancer progression and offers insights into potential therapeutic strategies.

Keywords:
invasionmacrophagesmetastasismigrationproteasestumor microenvironment

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Pericellular proteases are implicated in cancer invasion and metastasis via extracellular matrix degradation.
  • Emerging evidence highlights their role in modulating tumor progression through complex signaling pathways.
  • These proteases affect cell adhesion molecules, growth factors, cytokines, and kinases.

Purpose of the Study:

  • To review the regulation of pericellular proteolysis by cancer cells and their microenvironment.
  • To dissect the mechanisms through which pericellular proteases contribute to cancer progression.
  • To discuss the therapeutic potential of targeting pericellular proteolysis.

Main Methods:

  • Literature review of recent studies on pericellular proteases in cancer.
  • Analysis of regulatory mechanisms involving cancer cells and the tumor microenvironment.
  • Discussion of protease functions in cancer progression and metastasis.

Main Results:

  • Pericellular proteases are regulated by the tumor microenvironment.
  • These enzymes contribute to cancer progression through diverse mechanisms, including cleavage and shedding of key molecules.
  • Targeting pericellular proteolysis presents therapeutic opportunities.

Conclusions:

  • Understanding the regulation of pericellular proteolysis is crucial for cancer research.
  • Pericellular proteases are key drivers of cancer progression and metastasis.
  • Targeting these proteases offers a promising avenue for novel cancer therapies.