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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Hepatitis C transmission from viremic donors in hematopoietic stem cell transplant

H-H Hsiao1, Y-C Liu, H-C Wang

  • 1Division of Hematology/Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|November 5, 2014
PubMed

Insights

Hepatitis C virus (HCV) transmission during hematopoietic stem cell transplant (HSCT) is a risk. Donor pretreatment with antiviral therapy prevented HCV transmission in one HSCT recipient, highlighting the importance of undetectable HCV RNA before cell harvest.

Area of Science:

  • Hepatology
  • Transplant Immunology
  • Virology

Background:

  • Hepatitis C virus (HCV) transmission to hematopoietic stem cell transplant (HSCT) recipients from viremic donors is a significant clinical concern.
  • Allogeneic HSCT involves complex procedures where donor-derived infections can pose risks to recipients.

Observation:

  • This report details 3 cases of allogeneic HSCT from donors with HCV infections within a larger cohort of 265 HSCT procedures.
  • One case demonstrated successful prevention of HCV transmission to the recipient.

Findings:

  • Prevention of HCV transmission was achieved through donor pretreatment with peginterferon/ribavirin, leading to undetectable HCV viremia before stem cell collection.
  • This outcome underscores the efficacy of antiviral therapy in mitigating HCV transmission risk in the HSCT setting.

Implications:

  • Effective antiviral therapy and achieving HCV RNA seronegativity in donors prior to stem cell harvest are crucial for preventing HCV transmission in HSCT.
  • These findings emphasize the need for rigorous donor screening and management protocols to improve HSCT outcomes.

Keywords:
HCVHSCThematopoietic stem cell transplantationhepatitis C virustransmission prevention

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