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Updated: Apr 21, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism
Ilaria Zanotti1, Margherita Dall'Asta, Pedro Mena
1Department of Pharmacy, University of Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
Abstract:
Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.
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