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Updated: Apr 21, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

Published on: January 20, 2019

LOX-1 unlocks human plasma cell potential.

¹Immunology Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia; St Vincent's Clinical School, UNSW Australia, 390 Victoria Street, Darlinghurst NSW 2010, Australia.

|November 5, 2014

Summary

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Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) on dendritic cells supports plasmablast production. This pathway involves LOX-1 triggering and the cytokines APRIL and BAFF, offering new insights into immune responses.

Area of Science:

Immunology
Cell Biology
Cardiovascular Research

Background:

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is primarily recognized for its role in promoting atherosclerosis.
Dendritic cells are key antigen-presenting cells in the immune system, bridging innate and adaptive immunity.

Purpose of the Study:

To investigate the function of LOX-1 in dendritic cells beyond its established role in atherosclerosis.
To elucidate the mechanisms by which LOX-1 signaling in dendritic cells influences adaptive immune responses, specifically B cell differentiation.

Main Methods:

The study utilized dendritic cells stimulated via LOX-1.
Analysis of cytokine production (APRIL and BAFF) following LOX-1 activation.
Assessment of the impact on plasmablast differentiation and production.

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Main Results:

Triggering of dendritic cells through LOX-1 directly promotes plasmablast production.
LOX-1 activation in dendritic cells leads to the secretion of the cytokines APRIL (A Proliferation-Inducing Ligand) and BAFF (B-cell Activating Factor).
These cytokines, APRIL and BAFF, are crucial for supporting the differentiation and survival of B cells into plasmablasts.

Conclusions:

Dendritic cells, via LOX-1, can directly contribute to the generation of antibody-producing plasmablasts.
This LOX-1-mediated pathway highlights a novel role for dendritic cells in regulating humoral immunity.
The findings suggest potential therapeutic targets for immune modulation in conditions involving LOX-1 and B cell responses.