Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

45.9K
Overview
45.9K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.2K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.2K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

1.0K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.0K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

604
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
604
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

802
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
802
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

7
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
7

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment.

Molecular metabolism·2020
Same author

Electrothermal patches driving the transdermal delivery of insulin.

Nanoscale horizons·2020
Same author

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.

Diabetes, obesity & metabolism·2020
Same author

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK.

Hepatology communications·2020
Same author

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.

Cell metabolism·2020
Same author

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.

Neurology·2020

Related Experiment Video

Updated: Apr 21, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

7.9K

Macrophage subsets in atherosclerosis.

Giulia Chinetti-Gbaguidi1, Sophie Colin1, Bart Staels1

  • 1INSERM U1011, Institut Pasteur de Lille, 1, Rue du Professeur Calmette, BP 245, Lille 59019, France.

Nature Reviews. Cardiology
|November 5, 2014
PubMed
Summary
This summary is machine-generated.

Macrophage subsets in atherosclerosis plaques offer better insights into disease progression than total macrophage counts. Understanding these subsets is key to developing new treatments for vascular disease.

More Related Videos

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.0K
An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization
07:42

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

Published on: June 12, 2013

18.7K

Related Experiment Videos

Last Updated: Apr 21, 2026

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

7.9K
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.0K
An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization
07:42

An In vitro Model to Study Heterogeneity of Human Macrophage Differentiation and Polarization

Published on: June 12, 2013

18.7K

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Pathology

Background:

  • Macrophage accumulation in blood vessel walls is a key feature of atherosclerosis.
  • Environmental factors within atherosclerotic lesions modify macrophage functions.
  • Macrophage subsets, not just total numbers, indicate plaque phenotype and stability.

Purpose of the Study:

  • To review macrophage phenotypes in atherosclerotic lesions.
  • To discuss their roles in plaque progression and stability.
  • To emphasize relevance to human pathology.

Main Methods:

  • Review of existing literature on macrophage phenotypes in human atherosclerotic plaques.
  • Analysis of in vitro studies and their limitations in reflecting in vivo human pathology.

Main Results:

  • The relative proportions of different macrophage subsets are more indicative of plaque characteristics than total macrophage count.
  • Specific macrophage subsets play distinct roles in plaque development and stability.

Conclusions:

  • Further research into specific macrophage subsets is crucial for understanding atherosclerosis.
  • Targeting these subsets may offer novel therapeutic strategies for cardiovascular disease.
  • Bridging the gap between in vitro findings and human pathology is essential.