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Updated: Apr 21, 2026

Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
Published on: January 5, 2024
Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi
Chien-Shun Chiou1, Munirul Alam2, Jung-Che Kuo3
1Centers for Disease Control, Taichung, Taiwan nipmcsc@cdc.gov.tw.
Abstract:
A salmonella genomic island, designated SGI11, was found in 18 of 26 multidrug-resistant Salmonella enterica serovar Typhi isolates from Bangladesh. SGI11 was an IS1 composite transposon and carried 7 resistance genes that conferred resistance to 5 first-line antimicrobials. Eleven of the 18 SGI11-carrying S. Typhi isolates had developed resistance to high levels of ciprofloxacin.
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