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Multicentric myofibroblastic sarcoma.

Mihir Dilip Wechalekar¹, Oliver Ayres², Gelareh Farshid³

¹Rheumatology Unit, Royal Adelaide Hospital and Flinders University School of Medicine, Adelaide, South Australia, Australia.

BMJ Case Reports

|November 5, 2014

Summary

This summary is machine-generated.

This study details a rare case of synchronous, multicentric low-grade myofibroblastic sarcoma in a 62-year-old man. The tumor presented multifocally, a presentation previously undescribed for this type of sarcoma.

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Area of Science:

Oncology
Pathology
Rheumatology

Background:

Low-grade myofibroblastic sarcoma is a rare soft tissue tumor.
Metastatic potential is recognized, but multifocal presentation is not well-documented.

Observation:

A 62-year-old man presented with inflammatory polyarthritis and adhesive capsulitis, initially unresponsive to disease-modifying antirheumatic drugs.
Over several years, progressive knee restriction and nodule development occurred on hands, knees, and back.
Biopsies revealed a spindle cell neoplasm consistent with myofibroblastic sarcoma.

Findings:

The patient was diagnosed with synchronous, multicentric low-grade myofibroblastic sarcoma.
Histopathology showed an infiltrative growth pattern, mitotic figures, smooth muscle actin positivity, and myxoid changes.
This represents a novel multifocal presentation of myofibroblastic sarcoma.

Implications:

Highlights the importance of considering rare tumors in patients with atypical rheumatological presentations.
Suggests that myofibroblastic sarcoma can present synchronously and multicentrically.
May prompt further investigation into the potential for multifocal development in myofibroblastic sarcoma.