Jove
Visualize
Contact Us

Related Concept Videos

The Nucleosome Core Particle01:12

The Nucleosome Core Particle

2.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
2.6K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

12.0K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
12.0K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

6.6K
In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
6.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

22.4K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
22.4K
The Nucleosome01:19

The Nucleosome

3.9K
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
3.9K
The Nucleosome02:33

The Nucleosome

4.1K
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SMAdd-seq: probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing.

Nucleic acids research·2025
Same author

Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription.

Nature communications·2024
Same author

SMAdd-seq: Probing chromatin accessibility with small molecule DNA intercalation and nanopore sequencing.

bioRxiv : the preprint server for biology·2024
Same author

Kinetic Proofreading.

Annual review of biochemistry·2022
Same author

The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.

Nature communications·2022
Same author

Permutational analysis of <i>Saccharomyces cerevisiae</i> regulatory elements.

Synthetic biology (Oxford, England)·2020
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Apr 21, 2026

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

5.4K

Nucleosomes, transcription, and probability.

Hinrich Boeger1

  • 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064.

Molecular Biology of the Cell
|November 5, 2014
PubMed
Summary

This study explores probabilistic theories to understand random behavior in single gene molecules. It bridges experimental observations of chromatin structure with theoretical frameworks for stochastic processes.

Area of Science:

  • Molecular Biology
  • Biophysics
  • Theoretical Chemistry

Background:

  • Single ion channel molecule studies highlighted the need to address stochastic processes.
  • Recent experimental data on single gene molecule chromatin structure presents new challenges.

Purpose of the Study:

  • To develop theoretical frameworks for understanding stochastic behavior in gene regulation.
  • To connect experimental observations of chromatin structure with probabilistic theories.

Main Methods:

  • Theoretical modeling of molecular interactions.
  • Analysis of stochastic processes in biological systems.
  • Integration of experimental data on chromatin structure.

Main Results:

More Related Videos

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.1K
Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells
11:42

Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells

Published on: May 10, 2019

14.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates
09:13

Author Spotlight: Getting an A with the 3Cs: Chromosome Conformation Capture for Undergraduates

Published on: May 12, 2023

5.4K
Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.1K
Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells
11:42

Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells

Published on: May 10, 2019

14.1K
  • Development of probabilistic models for chromatin dynamics.
  • Insights into the random behavior of single gene molecules.
  • A framework for interpreting complex molecular behaviors.

    • Conclusions:

    • Probabilistic theories are essential for understanding single gene molecule behavior.
    • Bridging experimental and theoretical approaches advances molecular biology.
    • The study provides a foundation for future research in stochastic gene regulation.