[Gender-specific differences in hemodynamically stable patients with acute pulmonary embolism]

Area of Science:

• Cardiology
• Pulmonary Medicine
• Medical Diagnostics

Context:

• Pulmonary embolism (PE) is a life-threatening condition.
• Risk stratification of hemodynamically stable PE patients is crucial.
• Identifying gender-specific differences in PE can improve patient outcomes.

Purpose:

• To investigate gender-specific differences in acute pulmonary embolism (PE).
• To evaluate gender-specific differences in risk stratification of hemodynamically stable PE patients.
• To analyze the predictive value of cardiac troponin I (cTnI) and D-Dimer for right ventricular dysfunction (RVD) and submassive PE, respectively, in a gender-specific manner.

Summary:

• This retrospective study analyzed 129 PE patients, comparing clinical, laboratory, and technical parameters between genders.
• Female patients were older and had a higher incidence of submassive PE with elevated pulmonary artery pressure.
• Cardiac troponin I (cTnI) strongly correlated with RVD, showing greater predictive efficacy in males, while D-Dimer showed similar predictive value for submassive PE across genders.

Impact:

• Findings highlight that female PE patients are generally older and present with more frequent submassive PE.
• Cardiac troponin I (cTnI) is a significant predictor of RVD, with its effectiveness in risk stratification being more pronounced in male patients.
• This study provides insights into gender-specific nuances in PE presentation and risk assessment, potentially guiding tailored clinical management strategies.