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11C-acetate PET imaging in patients with multiple sclerosis
Kazushiro Takata1, Hiroki Kato2, Eku Shimosegawa2
1Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Plos One
|November 5, 2014
Summary
Positron emission tomography (PET) with (11)C-acetate shows increased uptake in patients with multiple sclerosis (MS). This imaging technique may aid in diagnosing MS by correlating with MRI lesion counts.
Area of Science:
- Neuroimaging
- Nuclear Medicine
- Radiochemistry
Background:
- Glial cell activation is a key feature of multiple sclerosis (MS) pathology.
- Acetate is selectively taken up by astrocytes in the central nervous system (CNS).
Purpose of the Study:
- To evaluate the effectiveness of positron emission tomography (PET) using (11)C-acetate for diagnosing MS.
- To investigate (11)C-acetate brain uptake in MS patients compared to healthy volunteers.
Main Methods:
- Six relapsing-remitting MS patients and six healthy volunteers (HV) underwent (11)C-acetate PET scans.
- Volume-of-interest and voxel-based statistical analyses were performed on co-registered MRI and PET data.
- Correlation between (11)C-acetate uptake and MRI lesion load (T1 and T2 weighted images) was assessed.
Main Results:
- Standardized uptake values (SUV) of (11)C-acetate were elevated in both white and gray matter of MS patients compared to HV.
- Voxel-based analysis showed significantly increased SUV in widespread white matter areas, especially subcortical regions, in MS patients.
- A significant correlation was found between (11)C-acetate SUV in white and gray matter and the number of T2 lesions and T1 black holes.
Conclusions:
- (11)C-acetate uptake is significantly increased in MS patients.
- The elevated (11)C-acetate uptake correlates with the number of MRI-detected lesions.
- Preliminary findings suggest (11)C-acetate PET is a promising tool for clinical MS examination.
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