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Related Experiment Videos

Epstein-Barr virus and the elderly host.

K E Schmader1, C M van der Horst, M E Klotman

  • 1Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.

Reviews of Infectious Diseases
|January 1, 1989
PubMed
Summary
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Epstein-Barr virus (EBV) is highly prevalent in adults over 60, with increasing antibody titers correlating with age. However, EBV-associated infectious mononucleosis is rare in the elderly and presents with milder symptoms.

Area of Science:

  • Virology
  • Gerontology
  • Immunology

Background:

  • Epstein-Barr virus (EBV) establishes lifelong latent infections and has transforming capabilities.
  • The implications of EBV activity in elderly hosts warrant investigation due to potential age-related immune system changes.

Purpose of the Study:

  • To review literature and hospital records to determine the activity and clinical manifestations of EBV in the elderly population.
  • To assess the seroprevalence and antibody titers of EBV in individuals over 60 years old.

Main Methods:

  • Literature review of published reports.
  • Analysis of hospital records.
  • Review of seroepidemiologic surveys on EBV antibody status in adults >60 years old.

Main Results:

Related Experiment Videos

  • Seroepidemiologic surveys indicate 90%-97% seropositivity for EBV in adults over 60.
  • Antibody titers to EBV increase with age, but this is not linked to clinical illness.
  • Infectious mononucleosis is uncommon in the elderly, presenting with fewer typical symptoms like pharyngitis, lymphadenopathy, and splenomegaly compared to younger adults.

Conclusions:

  • EBV is highly prevalent in the elderly, with age-associated increases in antibody titers.
  • Clinical manifestations of EBV, such as infectious mononucleosis, are less common and milder in the elderly.
  • While chronic mononucleosis-like syndromes are not observed, other EBV-associated diseases like nasopharyngeal carcinoma and B-cell lymphoproliferative disorders may occur in this age group.