Hyperpolarized magnetic resonance as a sensitive detector of metabolic function

Area of Science:

• Biomedical Imaging
• Biochemistry
• Medical Physics

Background:

• Hyperpolarized magnetic resonance (MR) offers noninvasive in vivo measurement of biochemical reactions.
• It is a powerful tool for assessing enzymatic activities within intact organs.
• Wider adoption is limited by a lack of accessible information on its scope and application.

Purpose of the Study:

• To provide fundamental principles and parameters for researchers interested in hyperpolarized MR.
• To guide the adoption of this technology for biochemical, biomedical, and medical research.
• To clarify the potential applications and limitations of hyperpolarized MR.

Main Methods:

• Review of essential physical concepts underlying hyperpolarized MR.
• Compendium of parameters to guide technique application.
• Inclusion of explicit examples to illustrate capabilities and constraints.

Main Results:

• The review elucidates the core physical principles of hyperpolarized MR.
• It offers practical guidance for assessing the technique's suitability for specific research contexts.
• Illustrative examples demonstrate both the strengths and limitations of the methodology.

Conclusions:

• Hyperpolarized MR is a valuable noninvasive tool for in vivo biochemical analysis.
• This review serves as a comprehensive guide for researchers seeking to utilize hyperpolarized MR.
• Understanding the principles and limitations is crucial for successful application in diverse research settings.