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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Personality and risk for postpartum depressive symptoms
S I Iliadis1, P Koulouris, M Gingnell
1Department of Women's and Children's Health, Uppsala University, Uppsala University Hospital, 751 85, Uppsala, Sweden, stavros.i.iliadis@gmail.com.
High neuroticism during pregnancy significantly increases the risk of developing postpartum depression. This finding highlights the importance of assessing personality traits for early intervention in maternal mental health.
Area of Science:
- Psychiatry and Mental Health
- Perinatal Psychology
- Epidemiology of Maternal Health
Background:
- Postpartum depression (PPD) affects 10-15% of new mothers, representing a significant childbirth complication.
- Understanding the predictors of PPD is crucial for timely intervention and improved maternal well-being.
Purpose of the Study:
- To investigate the association between specific personality factors and the development of postpartum depressive symptoms (PPDSs).
- To identify personality traits that may serve as risk indicators for PPD in non-depressed pregnant women.
Main Methods:
- Prospective study (BASIC study) involving 1037 non-depressed pregnant women.
- Assessment of depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS) and major depression diagnosis via the Depression Self-Rating Scale (DSRS).
- Evaluation of personality traits using the Swedish Universities Scale of Personality (SSP).
Main Results:
- High levels of neuroticism in late pregnancy were strongly associated with an increased risk of PPDSs at 6 weeks and 6 months postpartum (aORs ranging from 3.4 to 3.9).
- Trait anxiety (somatic and psychic) and mistrust were also linked to a higher risk of developing PPDSs.
- The association between high neuroticism and PPD remained significant even after adjusting for confounders.
Conclusions:
- Neuroticism is a significant predictor of postpartum depression in women who were not depressed during pregnancy.
- Personality assessment, particularly neuroticism, could aid healthcare professionals in identifying at-risk mothers for targeted support.
- Early identification of personality traits like neuroticism and anxiety may facilitate preventative strategies for postpartum depression.
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