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Related Experiment Videos

Elevated Ca2+ does not inhibit the 1,25(OH)2D3 response to phosphorus restriction.

D A Bushinsky1, C Nalbantian-Brandt, M J Favus

  • 1Department of Medicine, University of Chicago, Illinois 60637.

The American Journal of Physiology
|February 1, 1989
PubMed
Summary

Dietary phosphorus restriction stimulates 1,25-dihydroxyvitamin D3 production, even with elevated calcium levels from chronic metabolic acidosis. This indicates distinct regulatory pathways for vitamin D synthesis compared to parathyroid hormone stimulation.

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Renal Physiology

Background:

  • 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] biosynthesis is primarily stimulated by phosphorus restriction and parathyroid hormone (PTH).
  • Elevated serum ionized calcium (Ca2+) inhibits the PTH-stimulated pathway for 1,25(OH)2D3 production.
  • Chronic metabolic acidosis (CMA) can lead to increased serum Ca2+.

Purpose of the Study:

  • To investigate if elevated Ca2+ from CMA interferes with 1,25(OH)2D3 stimulation by dietary phosphorus restriction.
  • To compare the regulatory mechanisms of 1,25(OH)2D3 production stimulated by phosphorus restriction versus PTH.

Main Methods:

  • Rats were fed either a normal or low-phosphorus diet for 10 days.
  • Chronic metabolic acidosis was induced by adding ammonium chloride to drinking water.

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  • Serum levels of 1,25(OH)2D3, phosphorus, and Ca2+ were measured.

    • Main Results:

    • Low-phosphorus diet increased serum 1,25(OH)2D3 levels, irrespective of CMA.
    • CMA did not inhibit the rise in 1,25(OH)2D3 induced by phosphorus restriction.
    • Serum 1,25(OH)2D3 levels correlated inversely with phosphorus and directly with Ca2+.

    Conclusions:

    • Increased Ca2+ resulting from CMA does not inhibit the 1,25(OH)2D3 response to phosphorus restriction.
    • The mechanisms by which PTH and phosphorus restriction stimulate 1,25(OH)2D3 production differ.
    • Elevated Ca2+ blocks PTH-mediated 1,25(OH)2D3 increases but not those due to phosphorus restriction.