Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Anxiety: Overview

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Depression: Overview

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Depressive Disorders: MDD and Dysthymia

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

Self-Discrepancy and Its Effects

Self-Discrepancy and Its Effects

Self-discrepancy theory explains how people compare their actual self to their ideal and ought selves and how mismatches between these self-guides can lead to emotional distress. Developed by E. Tory Higgins, the theory distinguishes among three components of self-concept: the actual self, the ideal self, and the ought self. These refer respectively to how individuals perceive themselves, how they aspire to be, and how they believe they are obligated to be. Emotional well-being, self-esteem,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of asenapine in bipolar I patients meeting proxy criteria for moderate-to-severe mixed major depressive episodes: a post hoc analysis.

The Journal of clinical psychiatry·2015

Same author

Bipolar disorder: diagnostic issues.

The Medical journal of Australia·2010

Same author

Seizure threshold determination for electroconvulsive therapy: stimulus dose titration versus age-based estimations.

The Australian and New Zealand journal of psychiatry·2006

Same author

"GP Psych Opinion": evaluation of a psychiatric consultation service.

The Medical journal of Australia·2005

Search research articles

Related Experiment Video

Updated: Apr 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Depression and anxiety.

John W G Tiller¹

¹University of Melbourne, Melbourne, VIC, Australia. tillerj@ramsayhealth.com.au.

The Medical Journal of Australia

|November 6, 2014

Summary

This summary is machine-generated.

Comorbid depression and anxiety disorders are common in primary care, affecting up to 25% of patients. Effective treatments exist, yet many patients do not receive adequate care for these prevalent mental health conditions.

More Related Videos

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Related Experiment Videos

Last Updated: Apr 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Social Isolation Model: A Noninvasive Rodent Model of Stress and Anxiety

Published on: November 11, 2022

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

Area of Science:

General Practice
Psychiatry
Mental Health

Background:

Comorbid depression and anxiety disorders affect a significant portion of general practice patients, with high rates of co-occurrence.
Symptoms can be vague, necessitating thorough evaluation for accurate diagnosis.
Accurate diagnosis is crucial as both conditions require specific management strategies.

Purpose of the Study:

To highlight the prevalence and diagnostic considerations of comorbid depression and anxiety in primary care.
To review appropriate treatment modalities for these common mental health conditions.
To underscore the gap between treatment availability and patient access to beneficial care.

Main Methods:

Review of diagnostic approaches including careful history, examination, and investigations.
Utilization of rating scales for assessing illness severity and monitoring treatment.
Discussion of evidence-based psychological therapies and pharmacological interventions.

Main Results:

Cognitive behaviour therapy and antidepressants are beneficial for both depression and anxiety.
Benzodiazepines may offer short-term relief for anxiety and insomnia but do not treat depression and carry risks.
A substantial percentage of patients (40%) do not seek treatment, and many who do receive suboptimal care.

Conclusions:

Integrated treatment approaches are essential for managing comorbid depression and anxiety.
Addressing barriers to care is critical to improve outcomes for patients with these conditions.
Further research and clinical practice improvements are needed to ensure effective treatment delivery.