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Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 concentrations in children with

Jin Zhu1, Yu Fang2, Hai-Fei Wang3

  • 1Department of Otorhinolaryngology Head and Neck Surgery zhujin2698@163.com.

Respiratory Care
|November 6, 2014
PubMed

Insights

Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children impacts insulin-like growth factor-1 (IGF-1) and IGFBP-3 levels, with disease duration being a key factor, not severity. Treatment improves these growth factors, but age remains influential.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Growth Factor Research

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) is prevalent in children.
  • Growth and development can be affected by OSAHS.
  • Insulin-like growth factor-1 (IGF-1) and IGFBP-3 are crucial for growth.

Purpose of the Study:

  • To assess IGF-1 and IGFBP-3 concentrations in children with OSAHS.
  • To compare these concentrations based on disease severity and duration.
  • To evaluate the impact of surgical intervention on these factors.

Main Methods:

  • Fifty-one children with OSAHS underwent polysomnography to determine disease severity (mild, moderate, severe).
  • IGF-1 and IGFBP-3 levels were measured before and 3-6 months after tonsillectomy/adenoidectomy.
  • Statistical analyses were performed to compare concentrations by age, severity, and duration.

Main Results:

  • Pre-surgery, higher IGF-1 and IGFBP-3 were observed in younger children (<5 years) compared to older children (≥5 years).
  • Post-surgery, concentrations increased in both age groups but remained lower in older children.
  • Disease duration and age, but not severity, significantly influenced IGF-1 and IGFBP-3 levels, even after adjusting for other factors.

Conclusions:

  • Disease duration, rather than severity, significantly affects IGF-1 and IGFBP-3 concentrations in pediatric OSAHS.
  • These findings highlight the importance of early diagnosis and treatment to mitigate potential growth impacts.
  • Age is an independent factor influencing these growth mediators in children with OSAHS.
Abstract

Keywords:
childrendevelopmentdiseasedurationgrowthobstructive sleep apnea-hypopnea syndromepediatricseverity

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