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Six-Digit CPK and Mildly Affected Renal Function in McArdle Disease
George Spyropoulos1, Panagiotis Kratimenos2, Andrew D Mcinnes3
1University of Iowa Children's Hospital, Iowa City, IA 52242, USA.
Abstract:
A previously healthy, white 12-year-old girl presented with diffuse body aches and poor perfusion. She developed severe respiratory failure and marked rhabdomyolysis and was mechanically ventilated. Although her CPK peaked at 500,000 IU/L, her renal function was mildly affected and her creatinine did not exceed the 0.8 mg/dL. The rhabdomyolysis was gradually resolved following aggressive fluid hydration. The patient did not require dialysis and made a complete recovery. Genetic studies revealed the diagnosis of McArdle disease.
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