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Updated: Apr 21, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Significance of selected antioxidant enzymes in cancer cell progression
Rafał Jakub Bułdak1, Łukasz Bułdak, Michał Kukla
1Dr Rafał Jakub Bułdak, Medical University of Silesia, Katowice, School of Medicine with the Division of Dentistry, Department of Physiology in Zabrze, Jordana 19,, 41-808 Zabrze, Poland, tel./fax +48 32 272 23 62,
Abstract:
Antioxidant enzymes (AOEs), including superoxide dismutase isoenzymes (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) along with glutathione reductase (GR), reduced glutathione (GSH) and glutathione transferase (GST), are thought to be necessary for life process in all oxygen-metabolizing cells by removing reactive oxygen species (ROS). The biological significance of AOEs in transformed cells is still unclear, but their capacity to survive may be affected by changes in cellular process such as proliferation, invasiveness, migration, apoptosis and drug resistance. This review summaries the significance of antioxidant enzymes in cancer cell progression mainly in an in vitro context.
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