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Significant macular edema in a patient with cone dystrophy and improvement with acetazolamide treatment
Susan K Gelman1, Michael B Gorin
1Retinal Disorders and Ophthalmic Genetics Division, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California.
Purpose:
To describe a unique presentation and treatment course of a patient with an established diagnosis of cone dystrophy.
Methods:
Clinical examination, spectral domain optical coherence tomography, autofluorescence, fluorescein angiography, and electrophysiology testing were evaluated.
Results:
A patient with cone dystrophy diagnosed by clinical examination and electrophysiology testing displayed a large amount of macular intraretinal and subretinal fluid on spectral domain optical coherence tomography in both eyes, without obvious angiographic leakage. Intraretinal fluid resolved after 7 weeks treatment on oral acetazolamide therapy. The patient had subjective improvement in peripheral vision, though the visual acuity remained the same.
Conclusion:
Patients with cone dystrophy can accumulate intraretinal edema in the macula, which may respond to carbonic anhydrase therapy.
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