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Reversible vision loss and outer retinal abnormalities after intravitreal ocriplasmin injection
Aristomenis Thanos1, Jonathan Hernandez-Siman, Kyle V Marra
1*Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; †The Warren Alpert Medical School, Brown University, Providence, Rhode Island; ‡Retina Service, Division of Ophthalmology, Beth Israel Medical Center, Boston, Massachusetts; and §Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Vision loss after ocriplasmin injection for vitreomacular adhesion can resolve. A case study shows gradual visual recovery over three months, suggesting potential for photoreceptor restoration.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Pharmacology
Background:
- Ocriplasmin, a form of plasmin, treats vitreomacular adhesion.
- FDA reports indicate transient vision loss in 8% of patients post-injection.
- This case details vision recovery after ocriplasmin treatment.
Observation:
- A 55-year-old woman experienced severe vision loss two days after ocriplasmin injection.
- Ophthalmic examinations included spectral domain optical coherence tomography (SD-OCT).
- Distinct ellipsoid zone alterations in photoreceptors were noted via SD-OCT.
Findings:
- Patient's visual acuity and retinal changes gradually improved over three months.
- Recovery of the ellipsoid zone of photoreceptors was observed.
- This suggests a potential for spontaneous resolution of vision impairment.
Implications:
- Further research is needed to understand the mechanisms of vision loss and recovery.
- This case highlights the possibility of vision restoration after ocriplasmin-induced complications.
- Understanding these mechanisms could improve patient management and treatment protocols.
