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Updated: Jan 21, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Exudative retinal detachment as a presenting sign in Philadelphia chromosome-positive acute lymphoblastic leukemia
Matthew S J Katz1, David E Fingerhut, Gowtham Jonna
1Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
Purpose:
We present here a case of bilateral exudative retinal detachments in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia and describe the patient's response to induction chemotherapy and clinical course.
Methods:
A retrospective case study with fundus photographs and optical coherence tomography. A 46-year-old woman presented with bilateral exudative retinal detachments. A systemic evaluation revealed acute lymphoblastic leukemia.
Results And Conclusion:
This is an exceptional case in that the exudative retinal change so closely parallels systemic response to remission and relapse in a hematologic malignancy, and suggests that the clinical course of exudative retinal change may be a legitimate proxy for efficacy-or failure-of systemic therapy.
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