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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Idiopathic dilated cardiomyopathy: computerized anatomic study of relashionship between septal and free left

Paulo Sérgio Juliani1, Eder França da Costa2, Aristides Tadeu Correia1

  • 1Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Revista Brasileira De Cirurgia Cardiovascular : Orgao Oficial Da Sociedade Brasileira De Cirurgia Cardiovascular
|November 6, 2014
PubMed

Insights

In idiopathic dilated cardiomyopathy, left ventricular enlargement is proportional between septal and non-septal segments across all regions. This finding suggests uniform remodeling in dilated cardiomyopathy, impacting understanding of systolic dysfunction.

Area of Science:

  • Cardiology
  • Anatomical Pathology
  • Medical Imaging

Background:

  • Dilated cardiomyopathy (DCM) is characterized by ventricular deformation, leading to systolic dysfunction.
  • Ventricular remodeling details in DCM remain underexplored, hindering understanding of functional impairment and therapeutic development.

Purpose of the Study:

  • To assess proportional left ventricular (LV) internal transverse perimeter expansion in basal, equatorial, and apical regions in idiopathic DCM.
  • To compare septal and non-septal segment remodeling in idiopathic DCM versus normal hearts.

Main Methods:

  • Anatomical study of 28 human cadaver hearts (18 with idiopathic DCM, 10 normal).
  • Digital image capture of LV internal transverse perimeters in basal, equatorial, and apical regions.
  • Measurement of septal and non-septal segments and calculation of the septal and non-septal segment index.

Main Results:

  • No significant difference in the proportionality index between septal and non-septal segments was observed in either normal or idiopathic DCM hearts across the three regions.
  • Septal/non-septal index ratios in DCM vs. normal hearts: Base (1.86 vs. 1.99, P=0.46), Equator (2.18 vs. 2.22, P=0.79), Apex (3.56 vs. 2.96, P=0.11).

Conclusions:

  • Transversal dilatation of the LV internal perimeter in idiopathic DCM occurs proportionally between the septum and free wall segments.
  • LV remodeling in idiopathic DCM appears uniform across basal, equatorial, and apical regions regarding septal and non-septal wall expansion.
Abstract

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