Related Experiment Video
Updated: Apr 21, 2026

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
CT positive brain injury in mild TBI patients presenting with normal SAC scores
Brian O'Neil1, Rosanne Naunheim2, Robert DeLorenzo3
1Department of Emergency Medicine, School of Medicine, Wayne State University, 4201 St. Antoine, University Health Center 6-G, Detroit, MI 48201.
Introduction:
Traumatic brain injury accounts for over 1 million U.S. emergency department visits annually. A significant percentage of patients undergo CT scans to exclude intracranial bleeds. The Standardized Assessment of Concussion (SAC) is designed to rapidly determine whether a concussion has occurred, (0-30 scale, where ≥25 is considered normal). Although not intended to be used in isolation, results in the normal range are considered an indication of low suspicion of brain injury. This study evaluated the relationship between CT findings of structural injury (CT+) and performance on the SAC.
Methods:
We performed a prospective observational study on mild head-injured patients presenting to the emergency department who underwent CT scans and had SAC evaluations.
Results:
We enrolled 368 patients, of which 66 were read by a neuroradiologist as positive (CT+), with an average age of 46.7, and an average Glasgow Coma Scale of 14.85. 38.2% of these CT+ patients had a SAC score ≥25. There were no significant differences between time of injury and CT scan or SAC for those with high or low SAC scores. Both high and low SAC groups contained similar CT+ abnormalities (e.g., hematomas).
Conclusions:
These results indicate that a normal SAC score alone does not exclude intracranial injury.
More Related Videos
10:33Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
08:27Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
Published on: April 11, 2025