Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

45.9K
Overview
45.9K
T Cell Types and Functions01:24

T Cell Types and Functions

3.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.1K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

604
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
604
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.2K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.2K
Inflammatory Response01:28

Inflammatory Response

12.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.2K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

7
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
7

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emerging regulators of endothelial lipid metabolism in atherosclerosis.

Current opinion in lipidology·2026
Same author

Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry.

Scientific reports·2025
Same author

Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1.

Pharmacological research·2025
Same author

Inhibiting effect of LIPUS on epithelial-mesenchymal transition in lens epithelial cells.

Experimental eye research·2025
Same author

Refining the impact of early intermittent hyperlipidemia on atherosclerosis: Unveiling the role of neutrophil reprogramming, sex differences, gut microbiota, and maternal hypercholesterolemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

Cholesterol crystals in the pathogenesis of atherosclerosis.

Nature reviews. Cardiology·2024

Related Experiment Video

Updated: Apr 21, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

34.3K

Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function.

Xinbing Han, William A Boisvert1

  • 1William A. Boisvert, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA, Tel.: +1 808 692 1567, Fax: +1 808 692 1973,

Thrombosis and Haemostasis
|November 7, 2014
PubMed
Summary

Interleukin-10 (IL-10) influences atherosclerosis by regulating macrophage activity and lipid metabolism. This anti-inflammatory cytokine plays a critical role in managing inflammatory responses and cellular processes within artery walls.

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

11.5K

Related Experiment Videos

Last Updated: Apr 21, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

34.3K
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.0K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

11.5K

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Lipid Metabolism

Background:

  • Atherosclerosis involves lipid metabolism disorders and chronic inflammation.
  • Monocyte infiltration into artery walls leads to macrophage foam cell formation.
  • Interleukin-10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and T lymphocytes.

Purpose of the Study:

  • To review the multifaceted roles of IL-10 in mediating atherosclerosis.
  • To focus on IL-10's regulation of macrophage activities crucial for atherosclerosis development.

Main Methods:

  • Literature review of current knowledge on IL-10 and atherosclerosis.
  • Analysis of IL-10's impact on macrophage function and lipid metabolism.

Main Results:

  • IL-10 inhibits macrophage activation, matrix metalloproteinase, pro-inflammatory cytokines, and cyclooxygenase-2 expression.
  • IL-10 demonstrates a significant role in altering lipid metabolism within macrophages.
  • IL-10 modulates key macrophage activities central to atherosclerotic lesion progression.

Conclusions:

  • IL-10 exerts significant anti-atherosclerotic effects through its anti-inflammatory and lipid-modulating actions on macrophages.
  • Understanding IL-10's regulatory mechanisms offers potential therapeutic targets for atherosclerosis.
  • Macrophages are central players in atherosclerosis, and IL-10 critically influences their atherogenic potential.