[Therapy of aortic valve stenosis]

J D Widder1, J Bauersachs

  • 1Klinik für Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland, widder.julian@mh-hannover.de.

Der Internist
|November 7, 2014
PubMed

Insights

Calcific aortic stenosis, a common heart valve disease, requires valve replacement when severe. Treatment options include surgical replacement or transcatheter aortic valve implantation for high-risk patients.

Area of Science:

  • Cardiology
  • Valvular Heart Disease
  • Geriatric Medicine

Background:

  • Calcific aortic stenosis is the most prevalent heart valve disorder in Western populations.
  • It is a degenerative, progressive condition common in the elderly, with rising incidence due to demographic shifts.
  • Currently, no medical therapy exists, making valve replacement the sole treatment for severe cases.

Purpose of the Study:

  • To review the diagnostic criteria and therapeutic options for calcific aortic stenosis.
  • To discuss the management of complex cases, including low flow, low gradient aortic stenosis.
  • To outline treatment indications based on symptoms and patient risk stratification.

Main Methods:

  • Echocardiography is the primary diagnostic tool for assessing aortic stenosis severity and valve morphology.
  • Diagnostic criteria for severe aortic stenosis include valve area <1.0 cm², valve index <0.6 cm²/m², mean gradient >40 mmHg, and peak velocity >4.0 m/s.
  • Patient management is guided by symptom onset and progression, with regular reevaluation for asymptomatic individuals.

Main Results:

  • Severe aortic stenosis is defined by specific echocardiographic parameters.
  • Asymptomatic patients generally have a favorable prognosis but require monitoring.
  • Symptomatic patients experience a significant decline in prognosis, necessitating valve replacement.

Conclusions:

  • Surgical valve replacement is the gold standard treatment for aortic stenosis.
  • Transcatheter aortic valve implantation (TAVI) is the established standard therapy for high-risk patients, including the elderly and those with severe comorbidities.
  • Timely diagnosis and appropriate intervention are crucial for managing calcific aortic stenosis.

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